Beneficiary: Lucian Blaga University of Sibiu (https://www.ulbsibiu.ro/en/ )
Project title: ”Next generation computer aided research in cardiovascular disease management” Next CARDIO
Project Manager (Research Team Leader): Victor Sebastian Costache, Associate professor
Project financed by: Competitiveness Operational Programme 2014-2020
Priority Axis 1 – Research, Technological Development and Innovation (RD&I) to Support Economic Competitiveness and Business Development / ACTION 1.1.4 Attracting high-level personnel from abroad in order to enhance the RD capacity
Implementation period: 08th of September 2016 – 07th of September 2019
CONTEXT OF THE PROJECT
NextCARDIO is associated with domain 5 “health” and more specifically of the sub-domain 5.6. “studies and diagnostic methods and treatment for the most widespread causes of mortality and morbidity in Romania”, where it tackles cardiovascular diseases. The research questions of the project are focused towards aneurisms and aortic dissections, although the project results can be applied to any type of cardiovascular disease.
Cardiovascular disease is the number one killer in Europe and Romania. One of the most complex variety of cardiovascular pathology is the aortic disease, which can be classified in aneurysms and dissections and related syndromes. Aortic aneurysm is one of diseases associated with the highest mortality rate. Unfortunately, the number of cases of abdominal aortic aneurysm rupture has not changed for the last 20 years, representing 3-5% of annual deaths in people aged over 65 years.
In Romania aortic dissection Romania is considered a major emergency disease and the prevalence tends to follow the European model with a higher hospital mortality rate. The past 20 years didn’t bring further changes to epidemiological data. IRAD study (464 patients) reported a mortality of 27% for type A dissection and 29% for type B after surgery, and 53% and 9% after medical treatment (Eagle KA, Brukmann D, Isselbacher E et al. Predictive of mortality in patients with type A acute aortic dissections – results from the International Registry of Acute Aortic Dissection (IRAD). J Am Coll Cardiol 2000; 35: 323.)
GENERAL PROJECT OBJECTIVE
The NextCARDIO project creates an international research center and excellence initiative at the University Lucian Blaga Sibiu (LBUS/Lucian Blaga University of Sibiu).
The domain addressed is healthcare, with focus on Next-Generation Computer-Aided Cardiovascular Disease Management (CDM), and the new endovascular technologies associated to the computer aided models ad 3D simulators. CDM encompasses all stages of the medical process, i.e. preventive medicine, diagnostics, (clinical) treatment and post-treatement monitoring. The innovation provided by this initiative is the strong inter-disciplinary focus between medicine, technology and bio-engineering which facilitates breakthrough research, applications and innovations in treatement devices, simulation techniques and tools, and technology-based patient-centered support.
Through this objective LBUS aims to increase and diversify its research and innovation performance at national and European level in the field of healtcare particularly cardiovascular diseasease. The ultimate aim of NextCARDIO is to provide knowledge and solutions for high-tech (i.e. computer-aided) minimal-invasive innovative cardiovascular treatement and post-treatement products and services, which enable a longer and healthier life of the population, thus resulting in a higher quality of life of the invidual as well as lower societal and economical costs.
THE SPECIFIC PROJECT OBJECTIVES
- The NextCARDIO project creates an international research center and excellence initiative at the Lucian Blaga University of Sibiu (LBUS). The domain addressed is healthcare, with focus on Next-Generation Computer-Aided Cardiovascular Disease Management (CDM), and the new endovascular technologies associated to the computer aided models ad 3D simulators.
- The research institute will contain more research centers from LBUS, as those defined by the internal regulations, especially those on minim-invasive medicine. Together with the international research team brought by our project, the research institute will have a functional structure, capable of providing research, technological transfer and high scientific value.
- The ultimate aim of NextCARDIO is to provide knowledge and solutions for high-tech (i.e. computer-aided) minimal-invasive innovative cardiovascular treatment and post-treatment products and services, which enable a longer and healthier life of the population, thus resulting in a higher quality of life of the individual as well as lower societal and economical costs. This has an especially large societal impact as cardiovascular diseases are the number of mortality factor among population in Romania and Europe.
- Attract excellent scientists and international experts to LBUS to set-up and develop a team of researchers who will perform fundamental and applied research as well as experimental development in the field of cardiovascular diseases.
- Develop of an international research institute by bringing together intern research centers, especially those from the field of minim invasive medicine.
- Develop and prototype an innovative artificial smart diagnostic clinical tools for the management and treatment of cardiovascular diseases, who will assist the physician in choosing the optimal primary and secondary treatment for patients, and thereby preventing undesired clinical outcomes. The tools will we aided by Internet of Things and ICT solutions.
- Perform a study, to analyze and evaluate the results of the clinical tools by realizing an
- Increase the number of PhD students by around 15% in the Faculty of Medicine (based on the numbers of 2014) as well as that of post-doctoral researchers active in the faculty.
- Increase the number of international collaborations and apply for at least 4 projects in the HORIZON2020 programme, the Societal Challenges section.
The outputs and results developed by the project will facilitate the access of companies, hospitals and clinicians to state-of-the-art research, experimental developments and innovation results at LBUS. In addition, the project is at the interdisciplinary cross of engineering, bio-engineering and medicine, thus addressing three different smart specialisations with big potential of research and development for our country.
|No.||Published Articles resulted from NextCardio Project research||Authors
|1||Endovascular treatment of aortic dissection – Kinetic Elephant Trunk||A.Voican, D.Dorobanțu, A.Costache, C.Goia, E.Ciobanu, C.Leațu, N.Florescu, S.Sultan, V.Costache|
|2||Systematic Review and Patient-Level Meta-analysis of the Streamliner Multilayer Flow Modulator in the Management of Complex Thoracoabdominal Aortic Pathology||Niamh Hynes, Sherif Sultan, Ala Elhelali, Edward B. Diethrich, Edel P. Kavanagh, Mohamed Sultan, Florian Stefanov, Patrick Delassus, Liam Morris|
|3||Twelve-Months Outcomes of Patients Treated for Chronic Symptomatic Aortic Dissection Using the Streamliner Multilayer Flow Modulator||S. Sherif, N. Hynes, E. P. Kavanagh, V. S. Costache, F. Stefanov, A. Elhelali|
|4||Endovascular aortic repair with Multilayer graft for aortic dissection – Results from NextCardio||Victor S. Costache, Cristina Goia, Dan Dorobanțu, Sherif Sultan, Andreea Costache, Alexandru Voican, Nicolae Florescu|
|5||Endovascular management of chronic symptomatic aortic dissection with the Streamliner Multilayer Flow Modulator: Twelve-month outcomes from the global registry||S. Sherif , N. Hynes , E. P. Kavanagh , V. S. Costache , F. Stefanov , A. Elhelali|
|6||Automated suturing in less invasive aortic and mitral valve replacement surgery: reliable surgical ergonomics, reduced handling of exposed needles and shorter cardiopulmonary bypass duration||S.J. Sauer, J.A. Siordia, V.S. Costache, C.J. Lutz, P.A. Knight|
|7||First Two Mitral Valve Replacements via Right Lateral Mini Thoracotomy Using New Automated Annular Suturing Technology||Victor S. Costache, Juan A. Siordia, Jr., Charles J. Lutz, Jude S. Sauer, Peter A. Knight|
|8||A clinical review of early outcomes from contemporary flow modulation versus open, fenestrated and branch technologies in the management of thoracoabdominal aortic aneurysm||Sherif Sultan, Edel P Kavanagh, Edward Diethrich, Victor Costache, Mohamed Sultan, Fionnuala Jordan si Niamh Hynes|
|9||The role of multilayer flow modulator stents in the endovascular treatment of aortic dissection: a single center experience||V.Costache, D.M.Dorobantu, A.D.Costache, C.M.Goia, O.I.Stiru, R.A.White|
|10||Aortic valve surgery of the 21st century: sutureless AVR versus TAVI
|Costache VS, Moldovan H, Arsenescu C, Costache A.|
|11||Treatment of complex aortic aneurysms and dissections with the Multilayer Flow Modulator: Romanian registry experience||V.S.Costache, A.Boicean, A.Costache, C.Goia, S.Sultan, H.Moldovan, A.Santa, D.M.Dorobantu
|12||The role of multilayer stents in the treatment of aortic dissection: A single-center experience multilayer flow modulator stents in aortic dissection||Tatiana Melnic, Victor Sebastian Costache, Mircea Popitiu, Andreea Costache, Crina Solomon, Felix Farcas,|